Every idealist believes himself to have rational grounds for the faith that somewhere, and in some world, and at some time, the ideal will triumph, so that a survey, a divine synopsis of all time, somehow reveals the lesson of all sorrow, the meaning of all tragedy, the triumph of the spirit. But it is not ours to say, in the world in which we at present have to live from one day to another, and to follow the fortunes of (...) man from one newspaper to another,--when and how the true revelation of the world's meaning is faced and[ found. The Basic Writings of Josiah Royce, Vol. II, p. 1146.]. (shrink)

This essay, written by a biologist, a microbial ecologist, a biological anthropologist, and an anthropologist‐historian, examines tensions and translations in microbiome research on animals in the laboratory and field. The authors trace how research questions and findings in the laboratory are extrapolated into the field and vice versa, and the shifting evidentiary standards that these research settings require. Showing how complexities of microbiomes challenge traditional standards of causation, the authors contend that these challenges require new approaches to inferences used in (...) ecology, anthropology, and history. As social scientists incorporate investigations of microbial life into their human studies, microbiome researchers venture into field settings to develop mechanistic understandings about the functions of complex microbial communities. These efforts generate new possibilities for cross‐fertilizations and inference frameworks to interpret microbiome findings. Microbiome research should integrate multiple scales, levels of variability, and other disciplinary approaches to tackle questions spanning conditions from the laboratory to the field. (shrink)

Postnatally, heart muscle cells almost completely lose their ability to divide, which makes their loss after trauma irreversible. Potential repair by cell grafting or mobilizing endogenous cells is of particular interest for possible treatments for heart disease, where the poor capacity for cardiomyocyte proliferation probably contributes to the irreversibility of heart failure. Knowledge of the molecular mechanisms that underly formation of heart muscle cells might provide opportunities to repair the diseased heart by induction of (trans) differentiation of endogenous or exogenous (...) cells into heart muscle cells. We briefly review the molecular mechanisms involved in early development of the linear heart tube by differentiation of mesodermal cells into heart muscle cells. Because the initial heart tube does not comprise all the cardiac compartments present in the adult heart, heart muscle cells are added to the distal borders of the tube and within the tube. At both distal borders, mesodermal cell are recruited into the cardiac lineage and, within the heart tube, muscular septa are formed. In this review, the relative late additions of heart muscle cells to the linear heart tube are described and the potential underlying molecular mechanisms are discussed. BioEssays 26:248–261, 2004. Wiley Periodicals, Inc. (shrink)

A large number of cellular proteins bind ATP, frequently utilizing the free energy of ATP hydrolysis to drive specific biological reactions. Recently, a family of closely related ATP‐binding proteins has been identified, the members of which share considerable sequence identity. These proteins, from both prokaryotic and eukaryotic sources, presumably had a common evolutionary origin and include the product of the white locus of Drosophila, the P‐glycoprotein which confers multidrug resistance on mammalian tumours, and prokaryotic proteins associated with such diverse processes (...) as membrane transport, cell division, nodulation and DNA repair. A comparison of these various proteins provides valuable insights into the function and evolution of the multicomponent systems with which they are associated. (shrink)

Theravada Buddhism. A Social History from Ancient Times to Modern Colombo. Richard F. Gombrich. Routledge, London 1988. x, 237 pp. Hbk £20.00, pbk £7.95.

1. Introduction, par F. Best et al.--2. Histoire de la pédagogie, par Janine Assa et al.--3. Pédagogie comparée, par J. Auba et al.--4. Psychologie de l'éducation, par D. Lavenu et al.--5. Psychologie pédagogique, par F. Beaufils et al.--6. Aspects sociaux de l'éducation, par I. Berger et al.--7. Fonction et formation des enseignants, par F. Amiel-Lebigre et al.--8. Éducation permanente et animation socioculturelle, par P. Besnard et al.

1. Introduction, par F. Best et al.--2. Histoire de la pédagogie, par Janine Assa et al.--3. Pédagogie comparée, par J. Auba et al.--4. Psychologie de l'éducation, par D. Lavenu et al.--5. Psychologie pédagogique, par F. Beaufils et al.--6. Aspects sociaux de l'éducation, par I. Berger et al.--7. Fonction et formation des enseignants, par F. Amiel-Lebigre et al.--8. Éducation permanente et animation socioculturelle, par P. Besnard et al.

Values and the scope of scientific inquiry, by M. Farber.--The phenomenology of epistemic claims: and its bearing on the essence of philosophy, by R. M. Zaner.--Problems of the Life-World, by A. Gurwitsch.--The Life-World and the particular sub-worlds, by W. Marx.--On the boundaries of the social world, by T. Luckmann.--Alfred Schutz on social reality and social science, by M. Natanson.--Homo oeconomicus and his class mates, by F. Machlup.--Toward a science of political economics, by A. Lowe.--Some notes on reality-orientation in contemporary societies, (...) by A. Brodersen.--The eclipse of reality, by E. Voegelin.--Alienation in Marx's Political economy and philosophy, by P. Merlan.--The problem of multiple realities: Alfred Schutz and Robert Musil, by P. L. Berger.--Phenomenology, history, myth, by F. Kersten.--The role of music in Leonardo's Paragone, by E. Winternitz.--Alfred Schutz bibliography (p. [297]-306). (shrink)

Krabbe (2003, in F.H. van Eemeren, J.A. Blair, C.A. Willard and A.F. Snoeck Henkemans (eds.), Proceedings of the Fifth Conference of the International Society for the Study of Argumentation, Sic Sat, Amsterdam, pp. 641–644) defined a metadialogue as a dialogue about one or more dialogues, and a ground-level dialogue as a dialogue that is not a metadialogue. Similarly, I define a meta-argument as an argument about one or more arguments, and a ground-level argument as one which is not a meta-argument. (...) Krabbe (1995, in F.H van Eemeren, R. Grootendorst, J.A. Blair, C.A. Willard and A.F. Snoeck Henkemans (eds.), Proceedings of the Third ISSA Conference on Argumentation, Sic Sat, Amsterdam, pp. 333–344) showed that formal-fallacy criticism (and more generally, fallacy criticism) consists of metadialogues, and that such metadialogues can be profiled in ways that lead to their proper termination or resolution. I reconstruct Krabbe’s metadialogical account into monolectical, meta-argumentative terminology by describing three-types of meta-arguments corresponding to the three ways of proving formal invalidity he studied: the trivial logic-indifferent method; the method of counterexample situation; and the method of formal paraphrase. A fourth type of meta-argument corresponds to what Oliver (1967, Mind 76, 463–478), Govier (1985, Informal Logic 7, 27–33), and Copi (1986) call refutation by logical analogy. A fifth type of meta-argument represents my reconstruction of arguments by parity of reasoning studied by Woods and Hudak (1989, Informal Logic 11, 125–139). Other particular meta-arguments deserving future study are Hume’s critique of the argument from design in the Dialogues Concerning Natural Religion, and Mill’s initial argument in The Subjection of Women about the importance of established custom and general feeling vis-à-vis argumentation. (shrink)